منابع مشابه
Enterotoxigenic Escherichia coli infection induces tight junction proteins expression in mice
Enterotoxigenic Escherichia coli (ETEC) causes diarrhea in travelers, young children and piglets, but the precise pathogenesis of ETEC induced diarrhea is not fully known. Recent investigations have shown that tight junction (TJ) proteins and aquaporin 3 (AQP 3) are contributing factors in bacterial diarrhea. In this study, using immunoblotting and immunohistochemistry analyses, we found that E...
متن کاملTransmembrane proteins in the tight junction barrier.
Three types of transmembrane proteins have been identified within the tight junction, but it remains to be determined how they provide the molecular basis for regulating the paracellular permeability for water, solutes, and immune cells. Several of these proteins localize specifically within the continuous cell-to-cell contacts of the tight junction. One of these, occludin, is a cell adhesion m...
متن کاملSomatostatin regulates tight junction proteins expression in colitis mice.
Tight junction plays a critical role in intestinal defence. The alteration and perturbation of tight junction proteins could induce intestine barrier damage, and lead to the malabsorption of electrolytes and water. Previous studies had showed that colonic infection and inflammation could lead to the alteration of tight junction function, and somatostatin could protect intestinal epithelia. Thus...
متن کاملRole of tight junction proteins in gastroesophageal reflux disease
BACKGROUND Gastroesophageal reflux disease (GERD) is associated with impaired epithelial barrier function that is regulated by cell-cell contacts. The aim of the study was to investigate the expression pattern of selected components involved in the formation of tight junctions in relation to GERD. METHODS Eighty-four patients with GERD-related symptoms with endoscopic signs (erosive: n = 47) ...
متن کاملEndocytosis and Recycling of Tight Junction Proteins in Inflammation
A critical function of the epithelial lining is to form a barrier that separates luminal contents from the underlying interstitium. This barrier function is primarily regulated by the apical junctional complex (AJC) consisting of tight junctions (TJs) and adherens junctions (AJs) and is compromised under inflammatory conditions. In intestinal epithelial cells, proinflammatory cytokines, for exa...
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ژورنال
عنوان ژورنال: Progress in Biophysics and Molecular Biology
سال: 2003
ISSN: 0079-6107
DOI: 10.1016/s0079-6107(02)00037-8